王秀杰 女 博导 遗传与发育生物学研究所 电子邮件：xjwang@
通信地址：北京朝阳区北辰西路1号院2号中科院遗传发育所
邮政编码：100101
1. 非编码RNA与表观遗传修饰在哺乳动物胚胎干细胞多能性调控中的功能与机制研究。
利用新一代高通量测序技术，发现对哺乳动物胚胎干细胞多能性的获得与维持具有重要调控作用的microRNA、lncRNA等非编码RNA并研究部分非编码RNA的作用机制，研究RNA甲基化等表观遗传修饰对哺乳动物胚胎干细胞多能性的影响与机理。
2. 细胞分化与组织器官形成的调控机制研究。
整合各种高通量测序数据，解析哺乳动物细胞分化与主要组织器官形成的调控网络，挖掘调控哺乳动物细胞分化与主要组织器官形成的关键因子。
3. 生物信息学算法和软件的开发。
071021-生物信息学
基因组学 系统生物学和生物信息学
04-06 The Rockefeller University 博士
00-06 香港科技大学 硕士
98-06 南开大学 学士
2005-01--今 中科院遗传与发育研究所 研究员
04-12 The Rockefeller University 博士后
-,中国科学数据（中英文网络版）第一届编委会, 委员-,中国病理生物学会第十届理事会青年委员会, 委员-,第十二届全国青联科学技术界别工作委员会, 副主任委员-,第五届中国青年科技工作者协会, 常务理事-,Journal of Genetics and Genomics, 编委-今,BMC Genomics, 副主编-,北京生理科学会第十一届青年工作委员会, 委员-,中国遗传学会青年委员会, 副主任委员-,国家自然科学基金委重大研究计划, 指导专家组成员-,中国植物生理与分子生物学学会——植物分子生物学专业委员会, 委员-,中国细胞生物学学会——功能基因组信息学与系统生物学分会, 理事-,中国细胞生物学学会——染色体基因组蛋白组分会, 委员-,中国细胞生物学学会——功能基因组信息学与系统生物学分会, 理事-,Frontiers in Plant Genetics and
Genomics, 评审编辑-,中国医药生物技术协会生物医学信息技术分会, 委员-,Frontier of Biology, Associate Editors-in-Chief-,中国遗传学会青年委员会, 委员-,RNA Biology, 编委
干细胞研究进展系列讲座、 生物信息学应用、 生物信息学、 人类基因组学研究-进展与应用、 遗传发育学系列讲座
专利与奖励
2007年获得国家自然科学基金委杰出青年科学基金和美国杜邦公司青年科学家奖。2012年获得&中央国家机关五四青年奖章标兵&和&全国青年岗位能手&荣誉称号。2013年获得&中国青年五四奖章&荣誉称号，作为共同完成人获得&中国科学院杰出科技成就奖集体奖&。2014年作为第二完成人，获得国家自然科学奖二等奖。2015年获得&全国五一巾帼标兵&荣誉称号，入选科技部&中青年科技创新领军人才&。
现任国家重大科学研究计划项目首席科学家。担任 RNA Biology, BMC Genomics, Journal of Genetics and Genomics 等杂志编委。
（1）&nbsp中源协和生命医学奖创新突破奖,&nbsp其他,&nbsp2016（2）&nbsp“植物小RNA的功能及作用机理”获得国家自然科学奖,&nbsp二等奖,&nbsp国家级,&nbsp2016（3）&nbsp中国科学院大学生命科学学院“精品课程”,&nbsp院级,&nbsp2016（4）&nbsp中组部“万人计划领军人才”,&nbsp国家级,&nbsp2016（5）&nbsp教育部自然科学奖,&nbsp一等奖,&nbsp部委级,&nbsp2016（6）&nbsp非编码RNA重大研究计划指导专家组,&nbsp国家级,&nbsp2016（7）&nbsp中国科学院“优秀研究生指导教师”奖,&nbsp院级,&nbsp2016（8）&nbsp“全国五一巾帼标兵”荣誉称号,&nbsp国家级,&nbsp2015（9）&nbsp“全国三八红旗集体”荣誉称号,&nbsp国家级,&nbsp2015（10）&nbsp中国科学院京区“巾帼建功”先进集体,&nbsp,&nbsp院级,&nbsp2014（11）&nbsp科技部“中青年科技创新领军人才”,&nbsp国家级,&nbsp2014（12）&nbsp“哺乳动物多能性干细胞的建立与调控机制研究”获得国家自然科学奖,&nbsp二等奖,&nbsp国家级,&nbsp2014（13）&nbsp“干细胞多能性机理与转化研究”获得中国科学院杰出科技成就奖,&nbsp院级,&nbsp2013（14）&nbsp“血管稳态与重构的调控机制”指导专家组,&nbsp国家级,&nbsp2013（15）&nbsp第十七届“中国青年五四奖章”荣誉称号,&nbsp,&nbsp国家级,&nbsp2013（16）&nbsp第二届“中央国家机关青年五四奖章标兵”荣誉称号,&nbsp,&nbsp国家级,&nbsp2012（17）&nbsp国家杰出青年基金,&nbsp,&nbsp国家级,&nbsp2007（18）&nbsp杜邦青年科学家奖,&nbsp,&nbsp其他,&nbsp2007
（ 1 ）&nbsp启动子AFB4及其应用,&nbsp发明,&nbsp2012,&nbsp第 1 作者,&nbsp专利号: ZL .1（ 2 ）&nbsp启动子miR172c及其应用,&nbsp发明,&nbsp2012,&nbsp第 1 作者,&nbsp专利号: ZL .6（ 3 ）&nbsp启动子miR390及其应用,&nbsp发明,&nbsp2013,&nbsp第 1 作者,&nbsp专利号: ZL .0（ 4 ）&nbspath-eTM160在抑制microRNA160功能中的应用,&nbsp发明,&nbsp2014,&nbsp第 1 作者,&nbsp专利号: ZL .6（ 5 ）&nbspmiR-24 用于治疗或诊断心衰或患心衰倾向或,&nbsp发明,&nbsp2014,&nbsp第 1 作者,&nbsp专利号: ZL .2（ 6 ）&nbsp哌嗪衍生物作为p53分子调节剂的用途,&nbsp发明,&nbsp2016,&nbsp第 1 作者,&nbsp专利号: ZL .2（ 7 ）&nbsp无损检测细胞miRNA的表达量及确定细胞类型与状态的方法,&nbsp发明,&nbsp2016,&nbsp第 2 作者,&nbsp专利号: ZL .8（ 8 ）&nbsp一种RNA及产生该RNA的基因在调控水稻根系发育中的应用,&nbsp发明,&nbsp2014,&nbsp第 1 作者,&nbsp专利号: ZL .1（ 9 ）&nbsp用于鉴定或调控细胞多能性的关键基因、MICRORNA、其它非编码RNA或其组合,&nbsp发明,&nbsp2015,&nbsp第 2 作者,&nbsp专利号: ZL .8（ 10 ）&nbsp用于鉴定或调控细胞多能性的关键基因、MICRORNA、其它非编码RNA或其组合,&nbsp发明,&nbsp2015,&nbsp第 2 作者,&nbsp专利号: HK1163162
（ 1 ）&nbsp遗传学, 主持,&国家级,&11-12（ 2 ）&nbsp非编码RNA研究的新理论、新技术的发展及神经和肌肉早期发育过程中非编码RNA的系统发现, 主持,&国家级,&11-08（ 3 ）&nbsp影响水稻幼苗生长的激素互作网络研究和职务激素相关数据整合平台的建立, 主持,&国家级,&12-12（ 4 ）&nbsp高通量测序数据中新类型小分子非编码RNA的鉴定和相关生物信息学方法的开发, 主持,&部委级,&13-11（ 5 ）&nbspRNA介导的体细胞重编程技术, 主持,&部委级,&15-12（ 6 ）&nbsp细胞命运维持与转化的表观遗传调控作用与机制研究, 主持,&国家级,&18-08（ 7 ）&nbspmicroRNA或microRNA基因簇在干细胞多能性维持与分化过程中的作用与调控机制, 参与,&国家级,&15-12（ 8 ）&nbsp真核生物基因保守性的系统分析与功能研究, 主持,&国家级,&16-12（ 9 ）&nbspDNA与RNA甲基化表观修饰对单倍体胚胎干细胞多能性与所产生个体发育能力的影响和作用机制研究, 参与,&国家级,&16-12（ 10 ）&nbsp真核生物编码蛋白中未知重复序列的发现与功能研究, 主持,&国家级,&18-12（ 11 ）&nbsp真核生物非编码RNA自动鉴定、分类和功能预测系统的建立, 主持,&部委级,&11-12（ 12 ）&nbspMicroRNA介导mRNA中m6A甲基化形成的机制研究, 主持,&国家级,&19-12（ 13 ）&nbsp人类神经系统疾病相关重复序列的系统发现与调控机制研究, 主持,&部委级,&20-12（ 14 ）&nbsp主动脉瘤/夹层分子分型和诊治的精准医学研究, 参与,&国家级,&19-06（ 15 ）&nbsp植物调节功能lincRNA的发现及功能研究, 参与,&国家级,&12-12（ 16 ）&nbspRNA沉默技术的机理及其在转基因植物的应用, 主持,&国家级,&10-12
（1） 无，第十届世界生物技术工业国际年会，2013-06，无
（2） 无，国际干细胞协会第十一届年会，2013-06，无
（3） 无，国际干细胞协会第十届年会，2012-06，无
（4） 无，国际干细胞协会第九届年会，2011-06，无
项目协作单位
已指导学生吴旭东&&博士研究生&&071021-生物信息学&&郑淇&&博士研究生&&071021-生物信息学&&刘君&&博士研究生&&071021-生物信息学&&王欢&&博士研究生&&071021-生物信息学&&骆观正&&博士研究生&&071021-生物信息学&&赵营涛&&博士研究生&&071021-生物信息学&&王亦男&&博士研究生&&071021-生物信息学&&刘修营&&博士研究生&&071021-生物信息学&&吴华君&&博士研究生&&071021-生物信息学&&李玲玲&&硕士研究生&&430139-生物工程&&冯桂海&&博士研究生&&071021-生物信息学&&马英克&&博士研究生&&071021-生物信息学&&杨维&&博士研究生&&071021-生物信息学&&孙海汐&&博士研究生&&071021-生物信息学&&刘永鑫&&博士研究生&&071021-生物信息学&&陈同&&博士研究生&&071021-生物信息学&&徐阳&&硕士研究生&&085238-生物工程&&庞军玲&&博士研究生&&0710J3-生物信息学&&现指导学生李稳&&博士研究生&&071021-生物信息学&&王志敏&&博士研究生&&071021-生物信息学&&苑宝文&&硕士研究生&&0710J3-生物信息学&&王运浩&&博士研究生&&0710J3-生物信息学&&陈斌&&硕士研究生&&085238-生物工程&&张泽宇&&硕士研究生&&0710J3-生物信息学&&黄增辉&&博士研究生&&0710J3-生物信息学&&刘勇杰&&博士研究生&&071009-细胞生物学&&李长昊&&博士研究生&&0710J3-生物信息学&&
1. Zhang ZH, Liu XY, Guo XW,&Wang XJ*&and Zhang XR*. (2016) Arabidopsis&AGO3 predominantly recruits 24-nt small RNAs to regulate epigenetic silencing.&Nature Plants&2:. (*co-corresponding author)2. Li ZK, Wan HF, Feng GH, Wang LY, He ZQ, Wang YK,&Wang XJ, Li W*, Zhou Q* and Hu BY*. (2016) Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells.&Cell Research&26(1): 135-138.3. Li X, Cui XL, Wang JQ, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH,&Wang XJ, Li W* and Zhou Q*. (2016)&Generation and application of mouse-rat allodiploid embryonic stem cells.&Cell&164(1-2): 279-292.4. Xiao W, Adhikari S, Dahal U, Chen YS, Hao YJ, Sun BF, Sun HY, Li A, Ping XL, Lai WY, Wang X, Ma HL, Huang CM, Yang Y, Huang N, Jiang GB, Wang HL, Zhou Q,&Wang XJ, Zhao YL and Yang YG*. (2016) Nuclear m6A reader YTHCD1 regulates mRNA splicing.&Molecular Cell&61(4): 507-519.5. Zhang Y, Feng GH, Xu K, Wang LB, Cui P, Li YH, Wang CX, Teng F, Hao J, Wan HF, Tan YQ,&Wang XJ*&and Zhou Q*. (2016) A non-invasive method to determine the pluripotent status of stem cells by culture medium microRNA expression detection.&Scientific Reports&6: 22380.&(*co-corresponding author)6. Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang GB, Wang HL, Sang LS,&Wang XJ*, Yang YG* and Zhou Q*. (2015) m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.&Cell Stem Cell&(Cover Story) 16: 289-301. (*co-corresponding author)7. Castillo-González C, Liu XY, Huang CJ, Zhao CJ, Ma ZY, Hu T, Sun F, Zhou YJ, Zhou XP,&Wang XJ&and Zhang XR*. (2015) Geminivirus-encoded&TrAP&suppressor inhibits the histone methyltransferase SUVH4/KYP to counter host defense.&Elife&4: e06671.8. Shuai L, Wang YK, Dong MZ, Wang XP, Sang LS, Wang M, Wan HF, Luo GZ, Gu TT, Yuan Y, Feng CJ, Teng F, Li W, Liu XY, Li TD, Wang L,&Wang XJ, Zhao XY and Zhou Q*. (2015) Durable&pluripotency&and&haploidy&in&epiblast&stem cells derived from haploid embryonic stem cells in vitro.&Journal of Molecular Cell Biology&7(4): 326-337.9. Liu YL, Su HD, Pang JL, Gao Z,&Wang XJ, Birchler JA* and Han FP*. (2015) Sequential de novo centromere formation and inactivation on a chromosomal fragment in maize.&Proc. Natl. Acad. Sci. USA&112(11): E1263-71.10. Zhao YT, Wang M, Wang ZM, Fang RX,&Wang XJ* and Jia YT*. (2015) Dynamic and coordinated expression changes of rice small RNAs in response to Xanthomonas oryzae pv. oryzae.&Journal of Genetics and Genomics&42(11): 625-37. (*co-corresponding author)11. Luo GZ, Yang W, Ma YK and&Wang XJ*.&(2014) ISRNA: an integrative online toolkit for short reads from high-throughput sequencing data.&Bioinformatics&30: 434-436.12. Liu YX, Wang M and&Wang XJ*. (2014) Endogenous small RNA clusters in plants.&Genomics Proteomics Bioinformatics&12: 64-71.13. Gao W, Sun HX, Xiao HB, Cui GH, Hillwig ML, Jackson A, Wang X, Shen Y, Zhao N, Zhang LX,&Wang XJ*, Peters RJ* and Huang LQ*. (2014) Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in&Salvia miltiorrhiza.&BMC Genomics&15: 73.&(*co-corresponding author)14. Li W, Li X, Li TD, Jiang MG, Wan HF, Luo GZ, Feng CJ, Cui XL, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha JH, Xiao YM, Wang L, Liu ZH,&Wang XJ, Zhao XY and Zhou Q*. (2014) Genetic modification and screening in rat using haploid embryonic stem cells.&Cell Stem Cell&14: 404-414.15. Cui Y, Xiao Z, Chen T, Wei J, Chen L, Liu L, Chen B,&Wang XJ,&Li X and Dai JW*. (2014) The miR-7 identified from collagen biomaterial-based three-dimensional cultured cells regulates neural stem cell differentiation.&Stem Cells and Development&23: 393-405.16.&Wu HJ, Wang ZM, Wang M and&Wang XJ*. (2013) Wide-spread long non-coding RNAs (lncRNAs) as endogenous target mimics (eTMs) for microRNAs in plants.&Plant Physiology&161: 1875-84.17. Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao XY, Wang L,&Wang XJ*&and Zhou Q*. (2013) MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells.&Journal of Biological Chemistry&288: . (*co-corresponding author)18. Liu X, Zhang Y, Tong M, Liu XY, Luo GZ, Xie DF, Ren SF, Bai DH, Wang L, Zhou Q and&Wang XJ*. (2013) Identification of a small molecule 1,4-bis-[4-(3-phenoxy-ropoxy)-but-2-ynyl]-piperazine as a novel inhibitor of the transcription factor p53.&Acta Pharmacologica Sinica&34: 805–810.19. Li W, Yang W and&Wang XJ*. (2013) Pseudogenes: pseudo or real functional elements?&Journal of Genetics and Genomics&40: 171-177.20. Zhang XM, Ma YZ, Liu XY, Zhou Q* and&Wang XJ*. (2013) Evolutionary and functional analysis of the key pluripotency factor Oct4 and its family proteins.&Journal of Genetics and Genomics&40: 399-412. (*co-corresponding author)21. Ling HQ*, Zhao SC, Liu DC, Wang JY, Sun H, Zhang C, Fan HJ, Li D, Dong LL, Tao Y, Gao C, Wu HL, Li YW, Cui Y, Guo XS, Zheng SS, Wang B, Yu K, Liang QS, Yang WL, Lou XY, Chen J, Feng MJ, Jian JB, Zhang XF, Luo GB, Jiang Y, Liu JJ, Wang ZB, Sha YH, Zhang BR, Wu HJ, Tang DZ, Shen QH, Xue PY, Zou SH,&Wang XJ, Liu X, Wang FM, Yang YP, An XL, Dong ZY, Zhang KP, Zhang XQ, Luo MC, Dvorak J, Tong YP, Wang J, Yang HM, Li ZS*, Wang DW*, Zhang AM* and Wang J*. (2013) Draft genome of the wheat A-genome&Triticum urartu.&Nature&496: 87-90.22. Zhu H, Zhou Y, Castillo-González C, Lu A, Ge C, Zhao YT, Duan L, Li Z, Axtell MJ,&Wang XJ&and Zhang XR* (2013). Bidirectional processing of pri-miRNAs with branched terminal loops by&Arabidopsis&Dicer-like1.&Nature Structureal & Molecular Biology&20: . (Cover story)23. Li RC, Tao J, Guo YB, Wu HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY,&Wang XJ, Xu M* and Wang SQ*. (2013) In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice.&Circulation Research&112: 601-605.24. Zhang B#, Lv ZL#, Pang JL#, Liu YL, Guo X, Fu SL, Li J, Dong QH, Wu HJ, Gao Z,&Wang XJ*&and Han FP*. (2013) Formation of a functional maize centromere after loss of centromeric sequences and gain of ectopic sequences.&Plant Cell&25(6): . (*co-corresponding author)25. Fu SL, Lv ZL, Gao Z, Wu HJ, Pang JL, Zhang B, Dong QH, Guo X,&Wang XJ, Birchler JA* and Han F*. (2013)& De novo centromere formation on a chromosome fragment in maize.&Proc. Natl. Acad. Sci. USA&110: .26. Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vagbo CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM,&Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG* and He C*. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.&Molecular Cell&10: 18-29.27.&Shi ZM, Luo GZ, Fu LJ, Fang ZD,&Wang XJ&and Li XC*. (2013)&miR-9 and miR-140-5p target FoxP2 and are regulated by the social context of song behavior in zebra finches.&Journal of Neuroscience&16: .28. Niu YM, Zhao X, Wu YS, Li MM,&Wang XJ&and Yang YG*. (2013) N6-methyl- adenosine (m6A) in RNA: an old modification with a novel epigenetic function.&Genomics Proteomics Bioinformatics&11: 8-17.29. Li W, Shuai L, Wan HF, Dong MZ, Wang M, Sang LS, Feng CJ, Luo GZ, Li TD, Li X, Wang LB, Zheng QY, Sheng C, Wu HJ, Liu ZH, Liu L, Wang L,&Wang XJ, Zhao XY* and Zhou Q*. (2012) Androgenetic haploid embryonic stem cells produce live transgenic mice.&Nature&490: 407-411.30. Xu M, Wu HD, Li RC, Zhang HB, Wang M, Tao J, Feng XH, Guo YB, Li SF, Lai ST, &Zhou P, Li LL, Yang HQ, Luo GZ, Bai Y, Xi J, Gao W, Han QD, Zhang YY,&Wang XJ*, Meng X and Wang SQ*. (2012) Mir-24 regulates junctophilin-2 expression in cardiomyocytes.&Circulation Research&111: 837-841. (*co-corresponding author)31. Wu HJ, Zhang Z, Wang J, Oh DH, Dassanayake M, Liu B, Huang Q, Sun HX, Xia R,& Wu Y, Wang Y, Yang Z, Liu Y, Zhang W, Zhang H, Chu J, Yan C, Fang S, Zhang J, Wang Y, Zhang F, Wang G, Lee SY, Cheeseman JM, Yang B, Li B, Ming J, Yang L, Wang J, Chu CC*, Chen SY*, Bohert HJ, Zhu JK*,&Wang XJ*&and Xie Q*. (2012) Insights into salt tolerance from the genome of&Thellungislla salsuginea.&Proc. Natl. Acad. Sci. USA&109: . (*co-corresponding author)32. Wu HJ, Ma YK, Chen T, Wang M and&Wang XJ*. (2012) PsRobot: a web-based plant small RNA meta-analysis toolbox.&Nucleic Acids Research&40: W22-W28.33. Zhao YT, Wang M, Fu SX, Yang WC, Qi CK and&Wang XJ*. (2012) Small RNA profiling in two&Brassica napus&cultivars identifies microRNAs with oil production and developmental correlated expressions and new small RNA classes.&Plant Physiology&158: 813-823.34. Luo GZ, Hafner M, Shi ZM, Brown M, Feng GH, Tuschl T,&Wang XJ*&and Li XC*. (2012) Genome-wide annotation and analysis of zebra finch microRNA repertoire reveal sex-biased expression.&BMC Genomics&13: 727. (*co-corresponding author)35. Du YY, Gao C, Liu ZY, Wang L, Liu B, He F, Zhang T, Wang Y,&Wang XJ, Xu MJ, Zhu Y, Xu QB, Wang X* and Kong W*. (2012) Up-regulation of ADAMTS-7 by miR-29 expression mediates vascular smooth muscle calcification.&Arteriosclerosis, Thrombosis, and Vascular Biology&32: .36. Zhang C, Xu YY, Guo SY, Zhu JY, Huan Q, Liu HH, Wang L, Guo GZ,&Wang XJ&and Chong K*. (2012) Dynamics of brassinosteroid response modulated by negative regulator LIC in rice.&PLoS Genetics&8: e1002686.37. Woo J, MacPherson CR, Liu J, Wang H, Kiba T, Hannah MA,&Wang XJ, Bajic VB and Chua NH*. (2012) The response and recovery of the&Arabidopsis thaliana&transcriptome to phosphate starvation.&BMC Plant Biology&12: 62.38. Song XM, Li PC, Zhai JX, Zhou M, Ma LJ, Liu B, Jeong DH, Nakano M, Cao SY, Liu CY, Chu CC,&Wang XJ, Green PJ, Meyers BC and Cao XF*. (2012) Roles of DCL4 and DCL3b in rice phased small RNA biogenesis.&The Plant Journal&69: 462-474.39. Xu N, Li Y, Zhao YT, Guo L, Fang YY, Zhao JH,&Wang XJ, Huang L and Guo HS*. (2012) Identification and characterization of small RNAs in the hyperthermophilic archaeon&Sulfolobus solfataricus.&PLoS One&7: e35306.40. Sheng C, Zheng QY, Wu JY, Xu Z, Wang LB, Li W, Zhang HJ, Zhao XY, Liu L, Wang ZW, Guo CL, Wu HJ, Liu ZH, Wang L, He SG,&Wang XJ,&Chen ZG* and Zhou Q*. 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