Zebrafish Mms2 promotes K63-linked polyubiquitination and is involv...
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2012 Feb 1;11(2):157-66. doi: 10.1016/j.dnarep.. Epub
2011 Nov 3.Zebrafish Mms2 promotes K63-linked polyubiquitination and is involved in p53-mediated DNA-damage response.1, , , , .1College of Life Sciences, Capital Normal University, Beijing, People's Republic of China.AbstractThe ubiquitin-conjugating enzyme Ubc13 together with a Ubc/E2 variant (Uev) form a stable complex and mediate K63-linked polyubiquitination, which is implicated in DNA damage tolerance in yeast and mammalian cells. The zebrafish Danio rerio is a lower vertebrate model organism widely used in the studies of vertebrate development and environmental stress responses. Here we report the identification and functional characterization of two zebrafish UEV genes, Drmms2 and Druev1. Their deduced amino acid sequences indicate that the two UEV genes evolved separately prior to the appearance of vertebrates. Both zebrafish Uevs form a stable complex with DrUbc13 as well as Ubc13s from yeast and human, and are able to promote Ubc13-mediated K63 polyubiquitination in vitro, suggesting that their biochemical activities are conserved. Despite the fact that both zebrafish UEV genes can functionally replace the yeast MMS2 DNA-damage tolerance function, they exhibited differences in DNA-damage response in zebrafish embryos: ablation of DrMms2, but not DrUev1, enhances both spontaneous and DNA-damage induced expression of p53 effectors p21 and mdm2. In addition, DrUbc13 specifically binds Drp53 in an in vitro assay. These observations collectively indicate that zebrafish Mms2 and Ubc13 form a stable complex, which is required for p53-mediated DNA-damage response.Copyright (C) 2011 Elsevier B.V. All rights reserved.PMID:
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这里翻译一下句子：那个女孩有一头长发。有错误我会及时改正的pretty~是“美丽的”，她又高又苗条，“漂亮的”意思，她看起来十分美丽
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出门在外也不愁你能根据描述猜出是什么动物吗It,s thin and brown.It,s got four legs and a long tail.it likes eating dananas and climbing trees.It,s very clever.What is it?Z X C B N M M S Q E R D O G T Y U N O R Y Y A M K G KA K T U R F P B T OK L Y D B V A S Y UE H U I M O N K E Y R_百度作业帮
你能根据描述猜出是什么动物吗It,s thin and brown.It,s got four legs and a long tail.it likes eating dananas and climbing trees.It,s very clever.What is it?Z X C B N M M S Q E R D O G T Y U N O R Y Y A M K G KA K T U R F P B T OK L Y D B V A S Y UE H U I M O N K E Y R S I B I R D S J P D B O D H M A Z K L D B U A B E L E P HA N T D F S A H J R G H P 我会追分的 越早越好 我看时间的情况追分 100分也有可能
D O G狗M O N K E Y猴子B I R D鸟E L E P HA N T 大象是这个意思嚒
1考拉其余的看不懂，好像还有鸟 猴子 蚂蚁
第一个……是猴子吧a-b-c-d-e-f-g-h-i-j-k-l-m-n-o-p-q-r-s-t-u-v-w
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1. Liver and kidney are particularly rich in vitamin A.
肝脏和肾脏富含维生素A。
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2. Use only clean, Grade A, perfect eggs.
只用表面干净、无磕碰的A级鸡蛋。
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3. a diet that is deficient in vitamin A
缺乏维生素A的饮食
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4. She is in the A stream.
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5. The Navy has decided to cancel its contract for the A-12 Stealth attack plane.
海军方面已决定取消购买A-12隐形攻击机的合同。
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1．Maria is very shy,so she often gets nervous and even　gets　p＿　when　she　isin　a　party．2．After　finishing　your　test　paper,you　must　remember　to　check　all　the　questions　and　c＿　mistakes．
1.panic 2.correct