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摘要:（该内容经过伪原创处理，请直接查看目录）目标愈来愈多的同种异体肌腱用于前穿插韧带(Anterior Cruciate Ligament,ACL)重建,但关于异体腱的处置与保留办法并未杀青共鸣。本试验旨在剖析重复冻融处置对同种异体人肌腱的生物力学影响,为同种异体移植物的处置与保留供给实际根据。办法无菌情况下从3具自愿捐赠新颖尸首上取指浅屈肌腱24根、拇长屈肌腱6根,随机分为6组,即新颖组、冻融1次组、冻融2次组、冻融3次组、冻融5次组和冻融10次组,每组均含指浅屈肌腱4根,拇长屈肌腱1根。一次冻融周期采取-80℃冻存4天,25℃复融,各组肌腱阅历设定的冻融周期后检测其构造特征、力学性质及粘弹性变更等生物力学性质并停止比拟。成果与新颖组比拟,拉断实验中冻融5次组及冻融10次组最年夜负荷、最年夜应力均显著减小,差别均有统计学意义(P0.05)。应力松懈实验中,冻融5次组及冻融10次组应力松懈降低速度较快,与新颖组比拟差别均有统计学意义(P<0.05)。蠕变实验涌现类似成果,冻融5次组及冻融10次组肌腱在100N的拉力下更早松懈,发生的蠕变较年夜,与新颖组比拟差别有统计学意义(P0.05)。结论在同种异体移植物的保留方面上,深高温冻存-苏醒的周期与异体肌腱的生物力学性质降低有必定的关系,从本试验成果可以得出重复冻融的周期不宜跨越3个多周期重复冻融处置将减弱同种异体肌腱的生物力学性质,使得同种异体肌腱更轻易疲惫、断裂。关于现实的临床运用有必定的自创价值,应用过量周期重复冻融处置后的异体腱重建前穿插韧带,术后轻易招致移植物松懈,乃至断裂
Abstract:Target an increasing number of tendon allograft for interspersed ligament (anterior Cruciate ligament, ACL reconstruction, but the disposal of tendon allograft and retention approach has not been reached consensus. The purpose of this experiment was to analyze the biomechanical effects of repeated freezing and thawing treatment on the tendon of the allograft, and to provide the practical basis for the treatment and retention of allograft. Methods aseptic condition from three voluntary donation novel dead bodies on fetch superficial flexor tendon 24, hallux flexor hallucis longus tendon six, were randomly divided to 6 groups, namely, novelty group, frozen thaw group 1, group 2 times of freezing and thawing and freezing and thawing three times group, freezing and thawing five times group and freeze-thaw groups of 10 times, each containing superficial flexor tendon of finger four and flexor pollicis longus tendon 1. A freezing thawing cycle was taken for 4 days, 25 days, and degrees C, and the structural characteristics, mechanical properties and viscoelastic changes were detected after the tendon was set up by the freezing and thawing cycles. Achievements and group of novel analogy, breaking the freeze-thaw group 5 times and 10 times group most of the eve of the load, the biggest stress were significantly decreased, and the differences were statistically significant (P
0.05) freezing and thawing. In the stress relaxation test, the 5 groups of frozen thawed and frozen thawed 10 times of the stress relaxation to reduce the speed, and the difference between the new group were statistically significant (P<0.05). Creep experiments were similar to the results, the 5 groups of frozen thawed and frozen thawed 10 times in the tension of 100N, the creep of the larger, and compared with the new group, the difference was statistically significant (P0.05). Conclusion in the reservation of allograft, there is a certain relationship between the deep freeze and the recovery of the cycle and the biomechanical properties of the tendon. It can be concluded from the test results that the mechanical properties of the tendon can be weakened by repeated freezing and thawing cycles, which makes it easier to fatigue and fracture. On the clinical application of reality has a certain value, the application of excessive cycle of repeated freeze-thaw treatment of allograft tendon after the reconstruction of the anterior cruciate ligament, postoperative easily lead to graft, and even fracture
目录:摘要2-3Abstract3引言5-7第一章 材料与方法7-12&&&&1.1 材料7&&&&1.2 实验方法7-12&&&&&&&&1.2.1 实验材料准备7&&&&&&&&1.2.2 实验分组7-8&&&&&&&&1.2.3 反复冻融处理8&&&&&&&&1.2.4 生物力学测试8-12&&&&&&&&&&&&1.2.4.1 生物力学仪器操作8-9&&&&&&&&&&&&1.2.4.2 肌腱形态测量9-10&&&&&&&&&&&&1.2.4.3 预调节10&&&&&&&&&&&&1.2.4.4 应力松弛试验10&&&&&&&&&&&&1.2.4.5 蠕变试验10-11&&&&&&&&&&&&1.2.4.6 拉断试验11-12第二章 结果12-14&&&&2.1 大体形态观察12&&&&2.2 生物力学测试12-14&&&&&&&&2.2.1 两种肌健的总体比较12&&&&&&&&2.2.2 肌健的结构特性及力学特性12-13&&&&&&&&2.2.3 肌键的粘弹性变化13-14第三章 讨论14-18第四章 结论18-19附图19-21参考文献21-23综述23-34&&&&综述参考文献30-34攻读学位期间的研究成果34-35致谢35-36
原价：￥20.00元折价：￥1.00元
[1].庞胤. [D]. 河北医科大学.
2013[2].朱威宏. [D]. 中南大学.
2012[3].薛冬梅. [D]. 内蒙古农业大学.
2012[4].李宏兴. [D]. 河北医科大学.
2011[5].刘伟. [D]. 第二军医大学.
2012[6].雷钧. [D]. 广东工业大学.
2012[7].王琦. [D]. 青岛大学.
2011[8].丁杰. [D]. 泰山医学院.
2011[9].李士光. [D]. 泰山医学院.
2011[10].宋思昱. [D]. 山东中医药大学.
2011[11].冯大源. [D]. 辽宁中医药大学.
2011[12].张琳. [D]. 天津医科大学.
2010[13].郭珊成. [D]. 第三军医大学.
2011[14].左海斌. [D]. 第三军医大学.
2011[15].李建虎. [D]. 第四军医大学.（词条-相关词数量）
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