同型半胱氨酸测定与H型高血压的相关分析研究--《中国实用医药》2017年26期
同型半胱氨酸测定与H型高血压的相关分析研究
【摘要】：目的分析同型半胱氨酸(Hcy)与H型高血压的关系。方法 66例H型高血压患者(Hcy10μmol/L)作为观察组,选择同期66例入院体检的健康者(Hcy10μmol/L)作为对照组。采用酶循环法测定两组研究对象的血浆总同型半胱氨酸水平。比较两组研究对象Hcy水平及心脑血管事件发生率,比较观察组不同危险患者Hcy水平。结果入院时、1个月后、3个月后,观察组Hcy水平均高于对照组,差异具有统计学意义(P0.05);观察组患者心脑血管事件发生率为22.73%,明显高于对照组的9.09%,差异具有统计学意义(P0.05)。观察组中高危组患者Hcy水平水平明显高于中危组,差异具有统计学意义(P0.05)。结论同型半胱氨酸与高血压的发病有关,同型半胱氨酸升高,罹患高血压的几率升高,且发生心脑血管事件的几率也增高,且危险性越高。
【作者单位】：
【关键词】：
【分类号】：R544.1【正文快照】：
近年来,高血压成为诱发脑卒中和冠心病等疾病[1]的1　资料与方法独立危险因素,对公众的生命安全造成巨大威胁,欧洲心脏1.1　一般资料　选取2016年9月~2017年3月于本院治疗病学会等制定的治疗指南(2007年)中提出,高血压治疗目的66例高血压患者作为观察组,选择同期于本院进行身
欢迎：、、)
支持CAJ、PDF文件格式，仅支持PDF格式
&快捷付款方式
&订购知网充值卡
400-819-9993
《中国学术期刊（光盘版）》电子杂志社有限公司
同方知网数字出版技术股份有限公司
地址：北京清华大学 84-48信箱 大众知识服务
出版物经营许可证 新出发京批字第直0595号
订购热线：400-819-82499
服务热线：010--
在线咨询：
传真：010-
京公网安备75号工具类服务
编辑部专用服务
作者专用服务
不同年龄段高龄孕产妇临床特点与妊娠结局的分析
目的 研究高龄孕产妇的临床特点,及年龄与多种不良妊娠结局的关系.方法 收集日至12月31日在首都医科大学附属北京妇产医院分娩的3 151例高龄(分娩年龄≥35岁)产妇及同期分娩的6 098例非高龄产妇的临床资料及妊娠结局.剔除信息不全者,根据产妇的分娩年龄,分为高龄1组(35～ 39岁,2 683例)、高龄2组(≥40岁,366例)及对照组(＜35岁,6 098例)共3组,对3组产妇的临床资料进行对照分析,探索孕产妇年龄与妊娠期高血压疾病、妊娠期糖尿病、早产等多种妊娠风险之间的关系.结果 高龄1组、高龄2组和对照组产妇中,既往因剖宫产史(分别为27.39％、33.61％、5.53％)或既往子宫肌瘤剔除术史(2.80％、5.46％、0.72％)所造成瘢痕子宫者的比例分别比较,差异均有统计学意义(P均＜0.05).3组产妇中,孕前超重及肥胖者(分别为29.67％、27.05％、18.47％)、妊娠合并子宫肌瘤者(14.83％、19.95％、5.64％)的比例分别比较,差异均有统计学意义(P均＜0.05);通过辅助生殖技术受孕者(9.84％、15.03％、3.12％)也随年龄增加而呈现上升趋势(P＜0.05).3组产妇中,胎儿染色体异常(1.23％、3.01％、0.36％)及胎儿畸形(1.94％、4.37％、0.48％)的发生率,分别比较,差异均有统计学意义(P均＜0.01);妊娠期高血压疾病(9.84％、13.11％、9.23％)、糖尿病合并妊娠(1.83％、2.19％、0.72％)、妊娠期糖尿病(22.70％、28.42％、14.87％)、胎膜早破(25.57％、19.40％、31.42％)、前置胎盘(2.05％、2.46％、0.92％)、早产(8.35％、11.20％、5.51％)、产后出血(25.11％、18.31％、20.27％)及手术助娩(5.42％、2.33％、5.71％)的发生率分别比较,差异均有统计学意义(P均＜0.05).3组产妇中,初产妇的剖宫产率(45.42％、75.74％、21.33％)及经产妇的剖宫产率(51.46％、61.54％、30.95％)分别比较,差异均有统计学意义(P均＜0.05).3组产妇中,足月新生儿中巨大儿的发生率(10.80％、8.85％、7.96％)及新生儿转新生儿ICU率(9.63％、11.48％、5.21％)分别比较,差异均有统计学意义(P均＜0.05).结论 “二孩”政策调整后,高龄孕产妇的比例上升,其妊娠不良结局的相关风险增加,应加强高龄孕产妇妊娠的管理,对妊娠期并发症及合并症尽早进行预防及干预.
Abstract：
Objective To explore the association between maternal age and perinatal outcomes.Methods Totally,3 151 women with advanced maternal age and 6 098 women younger than 35 years old who delivered in Beijing Obstetrics and Gynecology Hospital in 2016 were recruited.Their clinic characteristics and perinatal outcomes were collected to divide into 3 groups based on delivery age,Group 1 (aged 35-39 years,2 683 cases),Group 2 (aged ≥40 years,366 cases) and the control group (aged＜35 years,6 098 cases).The association between maternal age and adverse perinatal outcomes were analyzed,including hypertensive disorder complicating pregnancy,gestational diabetes mellitus (GDM),preterm birth and postpartum hemorrhage.Results The rate of cesarean section history (27.39％,33.61％,5.53％) or previous myomectomy history (2.80％,5.46％,0.72％) were compared between the advanced maternal age groups and the control group,and the differences were statistically significant (P＜0.05).The percentage of prepregnancy overweight and obesity (29.67％,27.05％,18.47％),complicated with myoma (14.83％,19.95％,5.64％) were compared among the three groups,and the differences were statistically significant (P＜ 0.05).The percentage of pregnancy through assisted reproductive technology (9.84％,15.03％,3.12％) also had statistically significant differences (P＜0.05).The incidence of fetal chromosomal abnormalities (1.23％,3.01％,0.36％) and fetal malformations (1.94％,4.37％,0.48％) increased with the maternal age,with statistically significant differences (P＜0.01).The mobidity of hypertensive disorders (9.84％,13.11％,9.23％),pregestational diabetes mellitus (1.83％,2.19％,0.72％),gestational diabetes mellitus (22.70％,28.42％,14.87％),premature rupture of membranes (25.57％,19.40％,31.42％),placenta previa (2.05％,2.46％,0.92％),preterm birth(8.35％,11.20％,5.51％),postpartum hemorrhage (25.11％,18.31％,20.27％)and forceps delivery (5.42％,2.33％,5.71％) were compared,and the differences were statistically significant (P＜0.05).The cesarean section rate in primipara (45.42％,75.74％,21.33％) and multipara (51.46％,61.54％,30.95％) had statistically significant difference (P＜0.05).The proportion of macrosomia (10.80％,8.85％,7.96％) and neonates transferred into neonatal ICU (9.63％,11.48％,5.21％) in term neonates had statistically significant difference (P＜0.05).Conclusions Women with advanced maternal age increase after new family planning policy put into effect,so do the risk of adverse perinatal outcomes.Attention and interventions should be made to cope with the occurrence of adverse perinatal outcomes.
Zheng Xiaoli
Wu Shaowen
Zhang Weiyuan
作者单位：
100026,首都医科大学附属北京妇产医院产科
年，卷(期)：
Keywords：
在线出版日期：
基金项目：
北京市科学技术委员会首都临床特色应用研究与成果推广(Z182)Capital Special Subject on Application of Clinical Features of Beijing Municipal Science and Technology Commission of China
本文读者也读过
相关检索词
万方数据知识服务平台--国家科技支撑计划资助项目（编号：2006BAH03B01）(C)北京万方数据股份有限公司
万方数据电子出版社工具类服务
编辑部专用服务
作者专用服务
胺碘酮联合依那普利对高血压伴阵发性心房颤动患者复律及复律后窦性心律维持的影响
目的 观察胺碘酮联合依那普利对高血压伴阵发性心房颤动患者复律及复律后窦性心律维持的影响.方法 选择60例高血压伴阵发性心房颤动患者作为研究对象,按随机数字表法分为研究组和对照组各30例,对照组给予胺碘酮联合硝苯地平治疗,研究组给予胺碘酮联合依那普利,治疗1、3、7d后观察两组患者复律情况,成功转复者继续维持治疗,观察治疗后3、6、9、12个月窦性心律维持情况,复查超声心动图,测量左心房内径,采用电子血压计测量收缩压、舒张压.结果 研究组和对照组3、7d复律率分别为86.67％和63.33％,100％和86.67％,差异均有统计学意义(均P＜0.05).研究组和对照组治疗后6、9、12个月窦性心律维持率分别为83.33％和57.69％,80.00％和53.85％,76.67％和50.00％,差异均有统计学意义(x2=4.487、4.368、4.314,均P＜0.05).研究组与对照组治疗前、治疗后3、6、9、12个月的SBP、DBP差异均无统计学意义(均P＜0.05).研究组治疗12个月后左心房内径为(36.73±2.66)mm,明显低于对照组(38.78±2.64)mm,差异有统计学意义(P＜0.05).结论 胺碘酮联合依那普利能够提高高血压伴阵发性心房颤动患者复律率及复律后窦性心律维持率,有效控制心房扩大,改善临床预后.
Abstract：
Objective To observe the efficacy of amiodarone combined with enalapril in cardioversion of atrial fibrillation and maintenance of sinus rhythm in patients with hypertension and paroxysmal atrial fibrillation.Methods 60 patients with hypertension and paroxysmal atrial fibrillation were selected as study objects.They were divided into study group and control group according to the random number table,30 cases in each group.The control group was treated with amiodarone combined with nifedipine,the observation group was given amiodarone combined with enalapril.After 1,3 and 7 days of treatment,the rates of cardioversion of atrial fibrillation were observed.The rates of maintenance of sinus rhythm were observed after 3,6,9 and 12 months of treatment.The left atrial diameter was calculated by echocardiography.The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were detected by blood pressure monitor.Results The rates of cardioversion of atrial fibrillation in the study group and the control group after 3 and 7 days of treatment were 86.67％ and 63.33％,100.00％ and 86.67％,respectively,the differences were statistically significant (all P ＜ 0.05).The rates of maintenance of sinus rhythm in the study group and the control group after 6,9,and 12 months of treatment were 83.33％ and 57.69％,80.00％ and 53.85％,76.67％ and 50.00％,the differences were statistically significant (x2 =4.487,4.368,4.314,all P ＜ 0.05).There were no significant differences in SBP and DBP between the study group and the control group at 3,6,9 and 12 months after treatment (all P ＜0.05).The left atrial diameter of the study group after 12 months of treatment was (36.73 ± 2.66)mm,which was significantly lower than (38.78 ± 2.64)mm in the control group,the difference was statistically significant (P ＜ 0.05) Conclusion Amiodarone combined with enalapril can improve the conversion rate and the rate of sinus rhythm maintenance in patients with hypertension and paroxysmal atrial fibrillation,and effectively control the atrial enlargement and improve the clinical prognosis.
Zhang Jinyan
作者单位：
首都医科大学密云教学医院老年病科,北京市,101500
年，卷(期)：
Keywords：
在线出版日期：
本文读者也读过
相关检索词
万方数据知识服务平台--国家科技支撑计划资助项目（编号：2006BAH03B01）(C)北京万方数据股份有限公司
万方数据电子出版社