&&&促炎性细胞因子 在 生物学 分类中
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&&&&In primary cultured human SMC, EC, and monocyte-derived macrophages, pro-inflammatory cytokines or growth factors induced the expression of cathepsin L and its activity against extracellular collagen and elastin.
&&&&在原代培养的人SMC、EC和单核细胞来源的巨噬细胞中，促炎性细胞因子或生长因子诱导了Cat L的表达及其对胞外胶原蛋白和弹性蛋白的活性。
&&&&On the other hand, LPS also induced the expression of inflammatory cytokines such as TNF-a and IL-1 p after 4h and 1 h, respectively.
&&&&细胞因子TNF-α在4h时达到峰值，IL-1β在LPS作用1h时即见升高，说明促炎性细胞因子TNF-α和IL-lβ的升高早于趋化性细胞因子MCP-1和FKN。
&&&&The monocytes of the human beings, the research shows, recognize the lipoprotein material on the membrane of Mp by Toll like receptor 2 (TLR2) and further synthesize and secrete such proinflammatory cytokines as TNF- α , IL-1β , IL-6 and IL-12 through the activation of NF- κ B transcript.
&&&&研究表明,人体单核吞噬细胞主要通过TLR2识别支原体膜脂蛋白成分并由NF-kB途径介导IL-1β、TNF-α、IL-12等促炎性细胞因子的释放;
&&&&Conclusions
ox-LDL can obviously promote the product of IL-6 and TNF in vascular endothelial cells.
&&&&结论　ox LDL可促进血管内皮细胞产生促炎性细胞因子IL 6和TNF。
&&&&Background: Interleukin (IL)-18 is a proinflammatory cytokine and plays important regulating roles in various immune reactions.
&&&&背景:白细胞介素(IL)鄄18是一种促炎性细胞因子,对多种免疫反应具有重要调节作用。
&&&&The results of our previous experiments have shown that a-MSH had a protective action on EAE mice.
&&&&我们以前的实验发现，经腹腔多次注射α-MSH，对EAE小鼠有较好的保护作用，其免疫学机制涉及抑制促炎性细胞因子的产生和增加抑炎性细胞因子的分泌。
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To study the expression of IL1 receptor at protein level on superior cervical ganglion of normal and LPSstimulated rats. METHODS
Immunohistochemistry (ABC method) was used. RESULTS
There were plenty of IL1 receptor type I immnoreactive cells in the superior cervical ganglion of the normal rats. Most of them were median or small in size. Some of the small intensely fluorescent (SIF) cells were positive as well. Three hours after an administration of LPS (lipopolysaccharide) peritoneally, the number and... AIM
To study the expression of IL1 receptor at protein level on superior cervical ganglion of normal and LPSstimulated rats. METHODS
Immunohistochemistry (ABC method) was used. RESULTS
There were plenty of IL1 receptor type I immnoreactive cells in the superior cervical ganglion of the normal rats. Most of them were median or small in size. Some of the small intensely fluorescent (SIF) cells were positive as well. Three hours after an administration of LPS (lipopolysaccharide) peritoneally, the number and staining intensity of positive structures were not obviously changed. CONCLUSION
There exist IL1 receptors in the superior cervical ganglion of the rats. This suggests that peripheral vegetative neuron can give response to proinflammatory cytokines through the receptor bearing on their cell membrane. The present results have offered a morphological basis for cytokines signaling sympathetic nervous system.目的　在蛋白水平研究 IL - 1受体 I型在大鼠颈上节中的表达 .方法　免疫组织化学 ABC方法 .结果　在正常大鼠颈上节中 ,有大量 IL - 1受体 I型免疫反应阳性细胞 ,多为中、小型神经节细胞 ,也有一些小强荧光细胞 ( SIF)呈 IL- 1受体 I型阳性 . L PS免疫刺激后 ,阳性细胞的数量和染色强度无明显变化 .结论　大鼠颈上节神经元存在 IL- 1受体 ,表明周围植物性神经元能对促炎性细胞因子起反应 .本研究为免疫性细胞因子影响植物性神经元的信号活动提供了形态学基础 Objective
To study the effects of 17β-estradiol on the production of interleukin-6 (IL-6) and tumor necrosis factor (TNF) induced by oxidized low-density lipoproteins (ox-LDL) in vascular endothelial cells (VECs).Methods
The levels of IL-6 and TNF were measured in cultured human umbilical vein endothelial cells.Results
ox-LDL significantly increased the activity of IL-6 and TNF in cultured endothelial cells.With ox-LDL 20 mg/L,TNF activity was (0.72±0.08)μg/L and IL-6 activity was (92.28±6.29)U/ml,?P?<... Objective
To study the effects of 17β-estradiol on the production of interleukin-6 (IL-6) and tumor necrosis factor (TNF) induced by oxidized low-density lipoproteins (ox-LDL) in vascular endothelial cells (VECs).Methods
The levels of IL-6 and TNF were measured in cultured human umbilical vein endothelial cells.Results
ox-LDL significantly increased the activity of IL-6 and TNF in cultured endothelial cells.With ox-LDL 20 mg/L,TNF activity was (0.72±0.08)μg/L and IL-6 activity was (92.28±6.29)U/ml,?P?0.05).Conclusions
ox-LDL can obviously promote the product of IL-6 and TNF in vascular endothelial cells.17β-estradiol can significantly inhibit the production of IL-6 and TNF in endothelial cells induced by ox-LDL,but tamoxifen is able to block this effect.目的　研究氧化型低密度脂蛋白 (ox LDL)对内皮细胞产生促炎性细胞因子白细胞介素 6 (IL 6 )和肿瘤坏死因子 (TNF)的影响及 17β 雌二醇的作用。 方法　以体外培养的人脐静脉内皮细胞 (HUVEC)为模型 ,将ox LDL与HUVEC孵育及HUVEC经它莫西芬 (tamoxifen)和 (或 ) 17β 雌二醇预处理后 ,再与ox LDL孵育 ,检测培养液中IL 6和TNF的活性。结果　ox LDL可明显增加内皮细胞产生IL 6和TNF。ox LDL 2 0mg/L时 ,TNF为 (0 .72± 0 .0 8) μg/L ,IL 6为 (92 .2 8± 6 .2 9)U/经 17β 雌二醇预处理后 ,细胞在ox LDL作用后 ,IL 6和TNF活性与对照组比较 ,差异无显著性意义 ;它莫西芬和 17β 雌二醇处理内皮细胞后 ,再加ox LDL ,结果显示IL 6和TNF活性增高 ,与对照组比较 ,差异有显著性意义。结论　ox LDL可促进血管内皮细胞产生促炎性细胞因子IL 6和TNF。雌激素可明显抑制ox LDL引起的内皮细胞产生IL 6和TNF ,此作用可被它...目的　研究氧化型低密度脂蛋白 (ox LDL)对内皮细胞产生促炎性细胞因子白细胞介素 6 (IL 6 )和肿瘤坏死因子 (TNF)的影响及 17β 雌二醇的作用。 方法　以体外培养的人脐静脉内皮细胞 (HUVEC)为模型 ,将ox LDL与HUVEC孵育及HUVEC经它莫西芬 (tamoxifen)和 (或 ) 17β 雌二醇预处理后 ,再与ox LDL孵育 ,检测培养液中IL 6和TNF的活性。结果　ox LDL可明显增加内皮细胞产生IL 6和TNF。ox LDL 2 0mg/L时 ,TNF为 (0 .72± 0 .0 8) μg/L ,IL 6为 (92 .2 8± 6 .2 9)U/经 17β 雌二醇预处理后 ,细胞在ox LDL作用后 ,IL 6和TNF活性与对照组比较 ,差异无显著性意义 ;它莫西芬和 17β 雌二醇处理内皮细胞后 ,再加ox LDL ,结果显示IL 6和TNF活性增高 ,与对照组比较 ,差异有显著性意义。结论　ox LDL可促进血管内皮细胞产生促炎性细胞因子IL 6和TNF。雌激素可明显抑制ox LDL引起的内皮细胞产生IL 6和TNF ,此作用可被它莫西芬拮抗。 Background: Interleukin (IL)-18 is a proinflammatory cytokine and plays important regulating roles in various immune reactions. Aims: To observe the effects of IL-18 on the production of T helper type 1 (Th1) cytokines, such as interferon (IFN)-γ and IL-2, and the activation of nuclear factor (NF)-κB in the mononuclear cells, and to unravel the regulating role of IL-18 on the mononuclear cells and its mechanism. Methods: The murine splenic mononuclear cells (SMC) were previously stimulated by different doses... Background: Interleukin (IL)-18 is a proinflammatory cytokine and plays important regulating roles in various immune reactions. Aims: To observe the effects of IL-18 on the production of T helper type 1 (Th1) cytokines, such as interferon (IFN)-γ and IL-2, and the activation of nuclear factor (NF)-κB in the mononuclear cells, and to unravel the regulating role of IL-18 on the mononuclear cells and its mechanism. Methods: The murine splenic mononuclear cells (SMC) were previously stimulated by different doses of IL-18 or IL-18+IL-12, then the expression of IFN-γ mRNA and IL-2 ■ were examined by reverse transcriptase polymerase chain reaction (RT-PCR), and the production of their proteins were measured by enzyme-linked immunosorbent assay (ELISA). The activation of NF-κB was tested by electrophoretic mobility shift assay (EMSA). Results: After stimulated with IL-18, the production of IFN-γ protein in SMC supernatant increased according to the increasing concentrations of IL-18. While co-stimulated with 100 ng/ml IL-18 and different concentrations of IL-12, the production of IFN-γ protein increased according to the increasing concentrations of IL-12, significant difference could be found between the stimulated groups and the controls (P0.05). After stimulated with IL-18 or IL-18+IL-12, NF-κB was activated in SMC. Conclusions: The secretion of Th1 cytokine, IFN-γ, can be induced by IL-18 with or without IL-12 in mononuclear cells. NF-κB activation is involved in the signaling pathway of this process.背景:白细胞介素(IL)鄄18是一种促炎性细胞因子,对多种免疫反应具有重要调节作用。目的:观察IL鄄18对单个核细胞产生1型辅助性T细胞(Th1)细胞因子干扰素(IFN)鄄γ和IL鄄2的影响,及其对细胞内核因子(NF)鄄κB活化的影响,以揭示IL鄄18对单个核细胞的调节作用及其机制。方法:以不同浓度的IL鄄18或IL鄄18+IL鄄12刺激小鼠脾单个核细胞(SMC),采用逆转录聚合酶链反应(RT鄄PCR)检测IFN鄄γ和IL鄄2mRNA的表达,采用酶联免疫吸附测定检测IFN鄄γ和IL鄄2蛋白浓度,采用凝胶电泳迁移率改变实验(EMSA)检测NF鄄κB的活化。结果:IL鄄18刺激后,SMC培养上清液中的IFN鄄γ蛋白浓度随IL鄄18浓度的增高而相应增高;100ng/mlIL鄄18与不同浓度的IL鄄12共刺激后,IFN鄄γ蛋白浓度随IL鄄12浓度的增高而相应增高,与对照组相比有显著差异(P0.05)。IL鄄18或IL鄄18+IL鄄12刺激后,SMC中NF鄄κB活化。结论:IL鄄18可单独或与IL鄄12协同诱导单个核细胞分泌Th1细胞因子...背景:白细胞介素(IL)鄄18是一种促炎性细胞因子,对多种免疫反应具有重要调节作用。目的:观察IL鄄18对单个核细胞产生1型辅助性T细胞(Th1)细胞因子干扰素(IFN)鄄γ和IL鄄2的影响,及其对细胞内核因子(NF)鄄κB活化的影响,以揭示IL鄄18对单个核细胞的调节作用及其机制。方法:以不同浓度的IL鄄18或IL鄄18+IL鄄12刺激小鼠脾单个核细胞(SMC),采用逆转录聚合酶链反应(RT鄄PCR)检测IFN鄄γ和IL鄄2mRNA的表达,采用酶联免疫吸附测定检测IFN鄄γ和IL鄄2蛋白浓度,采用凝胶电泳迁移率改变实验(EMSA)检测NF鄄κB的活化。结果:IL鄄18刺激后,SMC培养上清液中的IFN鄄γ蛋白浓度随IL鄄18浓度的增高而相应增高;100ng/mlIL鄄18与不同浓度的IL鄄12共刺激后,IFN鄄γ蛋白浓度随IL鄄12浓度的增高而相应增高,与对照组相比有显著差异(P0.05)。IL鄄18或IL鄄18+IL鄄12刺激后,SMC中NF鄄κB活化。结论:IL鄄18可单独或与IL鄄12协同诱导单个核细胞分泌Th1细胞因子IFN鄄γ,NF鄄κB活化参与了这一过程的信号转导。&nbsp&相关查询
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