Arachidonic acid reciprocally alters the availability of transient and sustained dendritic K(+)... - Abstract - Europe PMC
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Department of Biology and Biochemistry, University of Houston, Houston, Texas , USA.
Journal Article, Research Support, U.S. Gov't, P.H.S., In Vitro
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Chemicals (10)
Gene Ontology (11)
Genes/Proteins (2)New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains.
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2009 Sep-O85(5):421-5. doi: 10.2223/JPED.1931.New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains. [Article in English, Portuguese]1, , , , , , , .1Faculdade de Medicina, Universidade Federal de Uberl?ndia (UFU), Uberl?ndia, MG, Brazil.AbstractOBJECTIVE: To evaluate the impact of new penicillin susceptibility breakpoints on resistance rates of pneumococcal strains collected from children with pneumonia.METHODS: Pneumococcal strains collected from patients admitted with pneumonia were isolated at the clinical analysis lab of Hospital de Clínicas de Uberl?ndia, Uberl?ndia, Brazil, and sent to Instituto Adolfo Lutz, S?o Paulo, Brazil, for further identification, serotyping and determination of antimicrobial susceptibility.RESULTS: From April 1999 to December
strains of pneumococcus were sent to Instituto Adolfo L of these, 195 (59%) were collected from patients with pneumonia. One hundred strains collected from patients & or = 12 years old were analyzed. The patients' age ranged from 1 to 12.6 years old (with mean age of 2.4 and median of 1.7 years). Forty-seven patients were male. The strains were isolated from blood (42%) and pleural fluid (58%). There were 35 oxacillin-resistant strains: according to the criteria defined by the Clinical and Laboratory Standards Institute (CLSI) in 2007 [minimum inhibitory concentration (MIC) & or = 0.06 microg/mL for susceptibility (S), 0.12 to 1 microg/mL for intermediate resistance (IR), and & or = 2 microg/mL for full resistance (FR)], 22 strains had IR and 11 strains had FR. According to the current breakpoints defined by the CLSI in 2008 (& or = 2 microg/mL for S, 4 microg/mL for IR and & or = 8 microg/mL for FR), only one strain had IR to penicillin. There was resistance to co-trimoxazole (80%), tetracycline (21%), erythromycin (13%), clindamycin (13%), and ceftriaxone (one strain simultaneously resistant to penicillin).CONCLUSIONS: When the new breakpoints for in vitro susceptibility were applied, penicillin resistance rates dropped 97%, from 33 to 1%.PMID:
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, January 2012, Pages 104–115
A chronological framework for a long and persistent archaeological record: Melka Kunture, Ethiopia, , , , , , , , , , , , , , , a Department of Earth & Planetary Science, University of California, Berkeley, CA 94720, USAb Berkeley Geochronology Center, 2455 Ridge Rd., Berkeley, CA, USAc Italian Archaeological Mission at Melka Kunture and Balchit, 22 rue Paul Gaubin, 63450 Le Crest, Franced Dipartimento di Scienze dell&Antichit&, Sapienza Universit& di Roma, Via Palestro 63, 00185 Rome, Italye Univ. Bordeaux 1, PACEA, UMR 5199, F-33400 Talence, Francef Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, GermanyNew 40Ar/39Ar geochronological data for several volcanic ash horizons from Melka Kunture, Ethiopia, allow for significantly more precise age constraints to be placed upon the lithostratigraphy, archaeology and paleontology from this long record. Ashes from the Melka Kunture Formation at Gombore yielded the most reliable age constraints, from 1.393&&&0.162&Ma (millions of years ago) near the base of the section to 0.709&&&0.013&Ma near the top. Dating the Garba section proved more problematic, but the base of the section, which contains numerous Oldowan obsidian artifacts, may be &1.719&&&0.199&Ma, while the top is securely dated to 0.869&&&0.020&Ma. The large ignimbrite from the Kella Formation at Kella and Melka Garba is dated to 1.262&&&0.034&Ma and pre-dates Acheulean artifacts in the area. The Gombore II site, which has yielded two Homo skull fragments, &twisted bifaces,& and a preserved butchery site, is now constrained between 0.875&&&0.010&Ma and 0.709&&&0.013&Ma. Additional ashes from these and other sites further constrain the timing of deposition throughout the section.Integration with previously published magnetostratigraphy has allowed for the first time a relatively complete, reliable timeline for the deposition of sediments, environmental changes, archaeology, and paleontology at Melka Kunture.Keywords40Ar/39Ar geochronology; Oldowan; Acheulean; Obsidian; Upper Awash; Ethiopia
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