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患者男性，48岁，以“左颞部头痛伴视物模糊20天”为主诉入院。
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患者男性，48岁，以“左颞部头痛伴视物模糊20天”为主诉入院;CT:稍高密度，骨质可见破坏，没有骨窗，不好看是不是侵蚀性的~MR：稍长T1稍长T2信号，内部可见坏死，边界清晰，增强后厚壁环形强化，强化明显~诊断：脑膜瘤》转移瘤~脑膜瘤内部出现坏死不一定代表是恶性的，主要看侵袭性~40岁以上的骨质破坏的病灶，转移瘤也须考虑~
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等答案，不知道怎么分析，谢谢楼主分享
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增强明显，颅骨破坏，考虑脑膜瘤，病史较短，肿瘤中心应该是坏死，恶性脑膜瘤可能？病人现已经麻醉了，等几天发病理。
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患者男性，48岁，以“左颞部头痛伴视物模糊20天”为主诉入院;CT:稍高密度，骨质可见破坏，没有骨窗，不好看是不是侵蚀性的~MR：稍长T1稍长T2信号，内部可见坏死，边界清晰，增强后厚壁环形强化，强化明显~诊断：脑膜瘤》转移瘤~脑膜瘤内部出现坏死不一定代表是恶性的，主要看侵袭性~40岁以上的骨质破坏的病灶，转移瘤也须考虑~
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脑外病变，恶性肿瘤，骨源性，转移性肿瘤可能性大，建议重点查乳腺，肺，肾脏及甲状腺。
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小弟愚见，脑外病变可能较高！等待病理结果！
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定位：脑外！定性：转移瘤可能性大！依据：CT:左侧颞叶团块样等密度，中心坏死囊变，相邻骨质变薄破坏！MR：T1等信号，T2等高信号，增强：可见环形厚壁不规则强化，相邻蛛网膜下腔变窄。鉴别：脑膜瘤：强化特点不如转移瘤明显！完善肿瘤筛查，重点乳腺、甲状腺及盆腔！
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病史：患者男性，48岁，以“左颞部头痛伴视物模糊20天”影像表现：CT:左颞部不规则肿块，跨蝶骨大翼向内外生长，呈略高密度，中心区见低密度，肿块未见明确钙化影。左侧眼球受推挤向前移位。MR表现：左颞部肿块，跨蝶骨大翼向内外生长，T1WI呈等、略低信号，内部见信号区，T2WI呈略高信号，中心见高信号，增强扫描明显强化。诊断：左颞部肿物：1、转移瘤？2、软骨肉瘤？3、脑膜瘤？分析：中年男性，骨来源肿瘤，并周围巨大软组织肿块，考虑恶性可能性大。恶性的骨肿瘤首先想到的是转移瘤。第二位想到的是软骨来源的肿瘤。脑膜瘤发生在这个部位的没有见过。
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有可能是鼻咽癌转移过来的
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zjllsj99 病理结果感谢楼主~
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zjllsj99 病理结果 感谢回馈，建议临床重点查肺，甲状腺，前列腺及胃肠道。
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不是我管的病人，听病人主管医生说家属一听转移瘤，放弃了，进一步检查也不做了
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感谢楼主提供病理结果，个人觉得在等待病理的同时或之前就应该筛查肿瘤，就有所斩获，而不是坐等病理结果！
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甲状腺癌颅骨转移！
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mariasam 感谢楼主提供病理结果，个人觉得在等待病理的同时或之前就应该筛查肿瘤，就有所斩获，而不是坐等病理结果！不是我的病人，不好多说，自己资历浅，做手术时候看到的片子，感觉自己诊断不清，就发了上来，谢谢大家关注
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颜面部钙化上皮瘤手术切除范围的研究.pdf
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颈部肿块的评价及处理（英文）
TITLE: Evaluation and Management of the patient with a neck mass
"This material was prepared by resident physicians in partial fulfillment of educational requirements established for the Postgraduate Training Program of the UTMB Department of Otolaryngology/Head and Neck Surgery and was not intended for clinical use in its present form. It was prepared for the purpose of stimulating group discussion in a conference setting. No warranties, either express or implied, are made with respect to its accuracy, completeness, or timeliness. The material does not necessarily reflect the current or past opinions of members of the UTMB faculty and should not be used for purposes of diagnosis or treatment without consulting appropriate literature sources and informed professional opinion."
________________________________________
Introduction
&&&&&&& A mass in the neck is a common clinical finding that presents in patients of all age groups.& The differential diagnosis may be extremely broad, and although most masses are due to benign processes,& malignant disease must not be overlooked.& Therefore, it is important for physicians to develop a systematic approach for developing a working diagnosis and management plan for the patient.
&&&&&&& The prominent landmarks of the neck are the hyoid bone, thyroid cartilage, cricoid cartilage, trachea, and sternocleidomastoid muscles.& In females, the cricoid cartilage is often the most palpable laryngeal structure, whereas in men, the thyroid cartilage is most easily palpable.& The SCM divides each side of the neck into two major triangles, anterior and posterior.& The anterior triangle is delineated by the anterior border of the SCM laterally, the midline medially, and the lower border of the mandible superiorly.&& The anterior triangle can be further divided into the inferior carotid (muscular), superior carotid, submandibular and submental triangles. The borders of the posterior triangles are the posterior border of the SCM anteriorly, the clavicle inferiorly, and the anterior border of the trapezius muscle posteriorly.& The omohyoid muscle divides this triangle into the subclavian and occipital triangles.&& The floor of the posterior triangle is formed by the splenius capitus, levator scapulae and scalene muscles.
The carotid bulb can be palpated near the anterior border of the SCM, near the level of the hyoid bone.& In slender persons or those with significant atherosclerosis, it can be mistaken for an abnormal mass, especially when asymmetric.&
&&&& &&&The lymphatic flow in the normal neck follows a predictable pattern and the presence of a mass in a lymphatic nodal chain location may offer clues to identifying a primary tumor or site of infection.& It is convenient to use the level system to describe the location of lymph node disease in the neck.& Level I contains the submental and submandibular nodes.& Levels II through IV contain lymph nodes along the jugular vein (upper, middle and lower).& Level V contains the lymph nodes located along the lower half of the spinal accessory nerve and the transverse cervical artery.& The supraclavicular nodes are included in the posterior triangle group.& The pre- and paratracheal nodes, precricoid (Delphian) node, and perithyroidal nodes are found within level VI.
General Considerations
&&&&&&& The first consideration should be the patient’s age group.& Three main age groups need to be considered:& pediatric (0 to 15 years), young adult (16-40 years) and late adult (&40 years).& In general, neck masses in children are more commonly inflammatory than congenital or developmental and more commonly congenital than neoplastic.& This distribution is similar in the young adult.& However, the first consideration in the late adult should be neoplasia.& The “rule of 80” is often applied, which states that 80% of non-thyroid neck masses in adults are neoplastic and that 80% of these masses are malignant.& A neck mass in a child, on the other hand, has a 90% probability of being benign.
&&&&&&& The next consideration should be the location of the mass.&& The location of the mass is particularly important with respect to congenital and developmental masses, because such lesions are consistent in location.& For metastatic neck masses, their location may be the key to identification of the primary tumor.& It is important despite the general considerations of age and location to treat each case individually.
Diagnostic Steps
&&&&&&& Evaluation of the patient with a neck mass must begin with a careful and complete history and a thorough head and neck examination.& A thorough review of the developmental time course of the mass, associated symptoms, personal habits, and prior trauma, irradiation or surgery is important.& Inquiries about smoking and alcohol use, fever, pain, weight loss, night sweats, exposure to tuberculosis, foreign travel and occupational/sexual history should be made.& In the late adult patient, symptoms of dysphagia, otalgia, and/or hoarseness with a smoking history most likely represent a neoplastic process.&
&&&&&&& The examiner should not pay undue attention to the neck mass neglecting the complete examination of the head and neck.& All mucosal surfaces of the nasopharynx, oropharynx, larynx and nasal cavity should be visualized by direct examination or by indirect mirror or fiberoptic visualization.& The oral and pharyngeal surfaces should be digitally palpated in addition to the neck mass.& Emphasis on location, mobility and consistency of the neck mass can often place the mass within a general etiologic grouping, such as vascular, salivary, nodal/inflammatory, congenital or neoplastic.
&&&&&&& A tender, mobile mass or a high suspicion of inflammatory adenopathy with an otherwise negative examination may warrant a clinical trial of antibiotics and observation not to exceed two weeks with close follow-up.
Diagnostic studies
Fine Needle Aspiration Biopsy (FNAB) -
&&&&&&& Currently, FNAB is the standard of diagnosis for neck masses and is indicated in any neck mass that is not an obvious abscess and persists following prescribed antibiotic therapies.& FNAB separates inflammatory and reactive processes that usually do not require surgery from neoplastic lesions, either benign or malignant.& It also may allay patient fears for malignant disease and helps the clinician differentiate carcinoma from lymphoma, which can prevent unnecessary panendoscopy.& There are no contraindications to FNAB.& Pulsatile neck masses may represent a carotid body tumor, and although many clinicians prefer not to biopsy these lesions, the fine gauge of the needle reduces bleeding complications.& Needle-track seeding of tumor is not a concern with the fine needles used today.& FNAB can also be performed in children, however, in a child younger than 2 years of age, immobilization may be necessary.& Children ages 2 to 7 can be sedated, and children above age 7 are fairly cooperative.& With thyroid aspiration in the pediatric population, it is preferable to have the child asleep.
&&&&&&& A skilled cytopathologist is critical to the efficacy of FNAB.& On-site evaluation carries the advantage of assessing specimen adequacy, which reduces the number of unsatisfactory specimens.& When a cytopathologist is not available on-site, the clinician may perform the FNAB and send the fixed slide to a regional specialist for review.& In these circumstances, a minimum of four separate needle passes and preparation of smears of good quality produce optimal results.
Nodal Mass Workup in the Adult
&&&&&&& If the clinical evaluation of a neck mass does not lead to a definitive diagnosis, malignancy must be excluded.& An asymptomatic cervical lump is the presenting symptom in about 12% of head and neck cancer cases.& Of these cancers, approximately 80% are squamous cell carcinoma (SCCa).& A history of alcohol and/or tobacco use should strengthen the clinician’s suspicion.& Also, ipsilateral otalgia with normal otoscopy should direct the examination to the tonsil, tongue base, supraglottis, and hypopharynx.& Another ear-related sign of a head and neck primary is unilateral serous otitis in the adult patient.& A careful nasopharyngeal exam is mandatory in this situation.
&&&&&&& If& careful repeated examination in the office does not identify a primary site, the entire aerodigestive tract must be examined endoscopically under anesthesia.& Biopsies should be performed on any suspicious mucosal lesions observed or in any& suspicious areas noted on CT or MRI.& If no lesions or imaging abnormalities are noted, biopsies of the nasopharynx, tonsils (including an ipsilateral tonsillectomy for jugulodigastric nodal disease), base of tongue, and pyriform sinuses should be obtained.& It is important at this time to examine thoroughly all areas of the aerodigestive mucosa, including the esophagus, to identify the primary or any synchronous lesions, which occur in between 10% and 20% of patients with head and neck malignancies.&
&&&&&&& In a recent study of SCCa of the neck from an unknown primary at the University of Florida, the primary tumor was able to be detected about 40% of the time.& In approximately 80% of these cancers, the base of tongue or tonsillar fossa was the culprit.& The ability to find the primary lesion greatly depended on suspicious findings during physical examination and on radiographic studies.& If no suggestive findings on exam or CT were obtained the yield dropped to below 20%.&
&&&&&&& If& a negative/equivocal FNAB is obtained yet suspicion for malignancy persists, an open excisional biopsy of the cervical lymph node may be performed.& The patient and surgeon should be prepared to proceed with a complete neck dissection depending on results of frozen sections.& If the biopsy shows only inflammatory or granulomatous changes, culture of the tissue is warranted.& A result of adenocarcinoma or lymphoma dictates closure of the wound and further workup and staging procedures prior to further treatment decisions.
Primary Tumors
Thyroid Masses
&&&&&&& Thyroid neoplasms, either benign or malignant, are a leading cause of anterior compartment neck masses in all age groups.& In the adult, they have a female predominance and are mostly benign.& Lymph node metastasis may be the initial symptom in 15% of papillary carcinomas and micrometastasis may be present& in over 90% of cases.& Fine-needle aspiration of thyroid masses has become the standard of care, replacing ultrasonography and radionuclide scanning in the assessment of thyroid nodules, although ultrasound may be performed to determine if the mass is cystic or to guide FNAB for small nodules.& It has been shown that FNAB has decreased the number of patients being treated with surgery, increased the number of malignant tumors found at surgery, and doubled the number of cases being followed up.& Unsatisfactory aspirates should be repeated, and negative aspirates should be followed up with a repeat examination and FNAB a month later.
&&&&&&& Lymphoma can occur in all age groups, but is a more common neoplastic process in pediatric and young adult groups.& As many as 80% of children with Hodgkin’s disease have a neck mass.& Progressive enlargement of a lateral neck mass is often the only sign of disease in the head and neck.& Systemic signs of fever, hepatosplenomegaly and diffuse adenopathy should be sought.& The mass often appears discrete, rubbery and nontender.& FNAB is the first line diagnostic test, and when it suggests lymphoma, an open biopsy with histologic examination is appropriate.& Work-up of head and neck lymphoma includes CT scans of the chest, abdomen, head and neck and bone marrow biopsy.
Salivary Tumors
&&&&&&& An enlarging mass anterior or inferior to the ear or at the angle of the mandible or submandibular triangle should raise suspicion for a primary salivary gland tumor.& Benign tumors are usually asymptomatic, however rapid growth, skin fixation or cranial nerve palsies (VII, XII and lingual) suggest malignant disease.& The diagnostic test of choice is open excisional biopsy-either submandibular gland excision or parotidectomy.& However, FNAB has been shown to reduce the number of patients being treated with surgery by 33%.& Some apparent neoplastic lesions on exam, may be intraparotid lymph nodes, localized sialadenitis, benign lymphoepithelial lesions or cysts.& The accuracy of FNAB in salivary glands is greater then 90% and more exact in benign than malignant tumors.& Its sensitivity is 90% with a specificity of approximately 80% for salivary glands.& If signs of malignancy are noted, FNAB may facilitate surgical planning and patient counseling.& In the case of the unknown primary, the surgeon and patient must be prepared for a total parotidectomy and facial nerve dissection with possible nerve sacrifice.
Carotid Body and Glomus Tumors
&&&&&&& These tumors are rare in the pediatric patient.& In adults, they classically appear in the upper anterior triangle at the carotid bifurcation as a pulsatile, compressible mass, which is mobile from side to side.& A bruit or thrill is present and in glomus vagale tumors, the ipsilateral tonsil may pulsate and/or deviate to the midline.& The diagnosis is confirmed by angiography or CT scan.& In the elderly patient, close observation or treatment with irradiation to arrest growth is adequate.& In young patients, a small tumor should be resected under hypotensive anesthesia.& Preoperative embolization is used routinely.& Preoperative measurement of catecholamine release should precede removal.
&&&&&&& Lipomas are ill-defined, soft masses usually appearing in patients over the age of 35 years.& They are usually asymptomatic and diagnosed by clinical findings.& Diagnosis is confirmed by excisional biopsy.
Neurogenic Tumors
&&&&&&& Neurogenic tumors or peripheral nervous system tumors arise from neural crest derivatives including Schwann cells, perineurial cells, and fibroblasts.& They include schwannomas (neurilemmoma and neurinoma), neurofibromas and malignant peripheral nerve sheath tumors (MPNST).& An increased incidence is associated with heritable neurofibromatosis (NF) syndromes.& Of the neurogenic tumors, schwannomas occur most commonly in the head and neck region.& Most are sporadic cases, and when extracranial, 25 to 45% will occur in the head and neck.& MPNST is uncommon in the head and neck region.
&&&&&&& Schwannomas are benign, solid neurogenic tumors that can occur at any age, but are most common between the ages of 20 and 50 years.& Those arising in the neck commonly occur in the parapharyngeal space.& They usually present as a solitary, slowly enlarging and painless mass.& On physical examination, they usually cause medial tonsillar displacement.& Those originating in the vagus nerve may present with hoarseness and/or vocal cord paralysis, and when originating in the sympathetic chain may be associated with Horner’s syndrome.& MRI is helpful in diagnosis and shows displacement of the internal carotid artery anteriorly and laterally.& For benign lesions, conservative surgical excision is the treatment of choice.
the surgeon and patient must be prepared for a total parotidectomy and facial nerve dissection with possible nerve sacrifice.
Carotid Body and Glomus Tumors
&&&&&&& These tumors are rare in the pediatric patient.& In adults, they classically appear in the upper anterior triangle at the carotid bifurcation as a pulsatile, compressible mass, which is mobile from side to side.& A bruit or thrill is present and in glomus vagale tumors, the ipsilateral tonsil may pulsate and/or deviate to the midline.& The diagnosis is confirmed by angiography or CT scan.& In the elderly patient, close observation or treatment with irradiation to arrest growth is adequate.& In young patients, a small tumor should be resected under hypotensive anesthesia.& Preoperative embolization is used routinely.& Preoperative measurement of catecholamine release should precede removal.
&& &&&&&Lipomas are ill-defined, soft masses usually appearing in patients over the age of 35 years.& They are usually asymptomatic and diagnosed by clinical findings.& Diagnosis is confirmed by excisional biopsy.
Neurogenic Tumors
&&&&&&& Neurogenic tumors or peripheral nervous system tumors arise from neural crest derivatives including Schwann cells, perineurial cells, and fibroblasts.& They include schwannomas (neurilemmoma and neurinoma), neurofibromas and malignant peripheral nerve sheath tumors (MPNST).& An increased incidence is associated with heritable neurofibromatosis (NF) syndromes.& Of the neurogenic tumors, schwannomas occur most commonly in the head and neck region.& Most are sporadic cases, and when extracranial, 25 to 45% will occur in the head and neck.& MPNST is uncommon in the head and neck region.
&&&&&&& Schwannomas are benign, solid neurogenic tumors that can occur at any age, but are most common between the ages of 20 and 50 years.& Those arising in the neck commonly occur in the parapharyngeal space.& They usually present as a solitary, slowly enlarging and painless mass.& On physical examination, they usually cause medial tonsillar displacement.& Those originating in the vagus nerve may present with hoarseness and/or vocal cord paralysis, and when originating in the sympathetic chain may be associated with Horner’s syndrome.& MRI is helpful in diagnosis and shows displacement of the internal carotid artery anteriorly and laterally.& For benign lesions, conservative surgical excision is the treatment of choice.
Congenital and Developmental Masses
Epidermal and Sebaceous Cysts
&&&&&&& These are the most common of the congenital masses occurring most often in the older age group.& Diagnosis is made clinically noting movement and elevation of the skin overlying the mass.& Excisional biopsy confirms the diagnosis.
Branchial Cleft Cysts
&&&&&&& A branchial cyst usually presents as a smooth, fluctuant mass underlying the SCM (second arch – most common) and often seems to appear rapidly after an upper respiratory tract infection.& If infection is recent, skin erythema and tenderness may be present.& Occasionally, purulent material may be expressed if a sinus tract is present.& These masses most commonly occur in late childhood or early adulthood, but may occur later in life also.& The more common 2nd branchial cleft cyst often has a tract coursing medially over the 12th nerve between the internal and external carotids to the tonsillar fossa.& The less common 1st branchial cyst occurs along the inferior or angle of the mandible or below the ear lobe.& Close association with the facial nerve is possible, so excision of this type may necessitate a total parotidectomy with facial nerve dissection.& In general, treatment is with initial control of infection, followed by surgical excision.& Methylene blue injection into a draining tract prior to excision may facilitate removal.
Thyroglossal Duct Cysts
&&&&&&& This is the most common congenital neck mass, which presents as a midline or near-midline mass that usually elevates on swallowing or protrusion of the tongue.& This clinical finding distinguishes the TDC from other midline masses, such as lymph nodes, dermoids or ectopic thyroid tissue, which are included in the differential.& Treatment is surgical removal including the midportion of the hyoid bone (Sistrunk procedure) after resolution of infection.
Vascular Tumors
&&&&&&& Lymphangiomas and hemangiomas are considered congenital lesions almost always present within the first year of life.& While lymphangiomas usually remain unchanged into adulthood, hemangiomas most often resolve spontaneously.& The lymphangioma mass is soft, doughy, and ill-defined.& CT or MRI may help define the extent of the neoplasm, and treatment includes excision for easily accessible lesions or those affecting vital functions.& Often surgical treatment precipitates further disease and recurrence is common.& Hemangiomas, on the other hand, often appear bluish and
are compressible.& CT or MRI again help the diagnosis and define the extent of disease.& Surgical treatment is reserved for lesions with rapid growth, associated thrombocytopenia or involvement of vital structures that fail medical therapy (steroids, interferon).
Inflammatory Disorders
Lymphadenitis
&&&&&&& Acute lymphadenitis is very common at some point in almost everyone’s life, especially during the first decade.& The presentation with marked tenderness, torticollis, trismus and dysphagia with systemic signs of infection is seldom a diagnostic challenge to the clinician and the source of the reactive lymphadenopathy is usually easily identified.& Initial treatment with directed antibiotic therapy and follow up is the rule.&
&&&&&&& Inflammatory nodes generally regress in size.& If the lesion does not respond to conventional antibiotics a biopsy is indicated after complete head and neck work-up.& Other indications for FNAB of lymphadenopathy include progressively enlarging nodes, a solitary and asymmetric nodal mass, supraclavicular mass or persistent nodal masses without active infectious signs.& Equivocal or suspicious FNAB in the pediatric nodal mass requires an open excisional& biopsy to rule out lymphoma or granulomatous disease.
Granulomatous lymphadenitis
&&&&&&& These infections usually develop over weeks and months, often with minimal systemic complaints of findings.& They may be the result of typical or atypical mycobacteria, actinomycosis, sarcoidosis, or cat-scratch fever (Bartonella).& The glands tend to be firm, with some degree of fixation and injection of the overlying skin.& They may suppurate and drain only to reform.& Tuberculosis is now rarely seen in our population and is more common in adults within the posterior triangle.& Atypical mycobacteria and cat-scratch fever are more common and more prevalent in the pediatric age group.& Atypical mycobacterial infection usually involves anterior triangle lymph nodes often with brawny skin, induration and pain, while cat-scratch commonly involves the preauricular or submandibular nodes.& Typical TB lymphadenitis often responds to anti-tuberculosis medications.& Cat-scratch often undergoes spontaneous resolution with or without antibiotic treatment.& Atypical mycobacterial infection usually responds to complete surgical excision.
&&&&&& &The differential diagnosis of neck masses is extensive and varies with the age of the patient at presentation.& A thorough work-up including an accurate history and complete head and neck examination often narrows the diagnostic possibilities, thus obviating the need for excessive testing and invasive procedures.& The fine needle aspiration biopsy has become an invaluable tool to aid clinicians in the evaluation of the neck mass and is safe, accurate, and cost-effective with minimal complications.& The possibility of malignancy in any age group, especially in the late adult group, should never be overlooked.& Close follow-up and aggressive pursuit of a diagnosis with appropriate work-up facilitates a timely and accurate treatment plan, which is essential to a favorable outcome.
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