RNA的delta值 delta值 CT值怎么计算

来源：蜘蛛抓取(WebSpider) 时间：2012-03-03 07:55 标签： delta值
本文欢迎转载，转载请注明：转载自中国学网： []
用户还关注
可能有帮助JOURNAL MENUFIND ISSUES
FIND ARTICLES
GET ACCESS
FOR CONTRIBUTORS
ABOUT THIS JOURNAL
SPECIAL FEATURES
Benjamin Heidrich1,2,11, Cihan Yurdaydın3, G&khan Kaba&am3, Boris A. Ratsch4, Kalliopi Zachou1,5, Birgit Bremer1, George N. Dalekos5, Andreas Erhardt6,&, Fehmi Tabak7, Kendal Yalcin8, Selim G&rel9, Stefan Zeuzem10, Markus Cornberg1,11, C.-Thomas Bock4, Michael P. Manns1,2,11, Heiner Wedemeyer1,2,11,* andfor the HIDIT-1 Study GroupDOI:&10.1002/hep.27102
Hepatology pages 87&97, Author Information1Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany2Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany3Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey4Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany5Department of Medicine and Research Laboratory of Internal Medicine, University of Thessaly, School of Medicine, Larissa, Greece6Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University, D&sseldorf, Germany7Department of Infectious Diseases, Istanbul University, Cerrahpasa School of Medicine, Istanbul, Turkey8Division of Hepatology, Dicle University, School of Medicine, Diyarbakir, Turkey9Division of Gastroenterology, Faculty of Medicine, Uluda& University, Bursa, Turkey10Medizinische Klinik I, Johann Wolfgang Goethe University, Frankfurt am Main, Germany11German Center for Infection Research (DZIF), partner site, Hannover-Braunschweig, Germany*Address reprint requests to: Prof. Dr. med. Heiner Wedemeyer, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover D-30625, Germany. E-mail: ; fax: +49-511-532-8662.Publication HistoryIssue published online: 26 JUN 2014Article first published online: 26 JUN 2014Accepted manuscript online: 28 FEB AM ESTManuscript Accepted: 24 FEB 2014Manuscript Received: 22 NOV 2013
ARTICLE TOOLS
Interferon alpha is the only treatment option for hepatitis delta virus (HDV). Trials investigating the efficacy of pegylated interferon alpha (PEG-IFNa) showed HDV RNA negativity rates of 25-30% 24 weeks after therapy. However, the clinical and virological long-term outcome of HDV-infected patients treated with PEG-IFNa is unknown. We performed a retrospective-prospective follow-up of 77 patients treated for 48 weeks with either PEG-alfa-2a and adefovir (ADV) or either drug alone in the Hep-Net-International-Delta-Hepatitis-Intervention-Study 1 (HIDIT-1) trial. Long-term follow-up data were available for 58 out of 77 patients (75%) with a median time of follow-up of 4.5 (0.5-5.5) years and a median 3 visits per patient. Patients treated with ADV alone received retreatment with PEG-IFNa (48% versus 19%; P = 0.02) more often. Hepatitis B virus surface antigen (HBsAg) became negative in six PEG-IFNa-treated patients until the end of long-term follow-up (10%). Sixteen patients tested HDV RNA-negative 6 months after PEG-IFNa treatment who were entered in the long-term follow-up study. Out of these, nine individuals tested HDV RNA-positive at least once during further long-term follow-up, with seven patients being HDV RNA-positive at the most recent visit. Clinical endpoints (liver-related death, liver transplantation, hepatic decompensation, hepatocellular carcinoma) were observed in three PEG-IFNa-treated (8%) and three ADV-treated (14%) patients during posttreatment long-term follow-up with an overall annual event rate of 2.5% (4.9% in cirrhosis). Sequencing confirmed the reappearance of pretreatment virus strains in all cases. Conclusion: Late HDV RNA relapses may occur after PEG-IFNa therapy of hepatitis delta and thus the term sustained virological response should be avoided in HDV infection. The annual posttreatment rate of clinical events in hepatitis delta patients eligible for PEG-IFNa therapy is about 2.5% and 4.9% in patients with cirrhosis. (Hepatology -97)

我要回帖

更多关于 delta值 的文章

 

随机推荐