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Storm Smart is the largest hurricane protection company in the state of Florida and has the most comprehensive line of products available including aluminum roll downs, storm catcher screens and impact resistant windows and doors.
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Hurricanes typically aren’t something people get excited about, so why would you want to throw or attend a hurricane party? Hurricane parties were developed in southern hurricane areas of the U.S., namely in Florida. They make the best of a…
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Built by .What is the STOTM - Second Thursday Of The Month club?
| LinkedIn
The STOTM club is held in Perth and is a sister event of the Last Tuesday Of The Month club which was founded in Melbourne in 2013, the First Wednesday Of The Month club in Sydney, the First Thursday Of The Month club in Canberra, the Second Wednesday Of The Month club in Brisbane and the Third Thursday Of The Month club in Adelaide.
There have been many discussions over the years about a predictable gathering for the Perth ICT and Information Security&community, the time has come.&
We welcome you to join our STOTM club. The events are invite only to maintain the numbers, and are held in Perth on the Second Thursday Of The Month - so it is easy to remember!
STOTM maintains a strong no sales stance, there will be no death by PowerPoint, we may have a brief&(10 min)&informal discussion on a topic of interest, not a sales pitch.&
There may be complimentary drinks supplied through the support of a sponsor. (If you are, or you know of, a prospective sponsor&(recruiter, supplier, vendor)&please contact Matt Tett for further information).&
STOTM is a mix of professionals from: Government, Information Technology, Communications, Security, Technical, IT Risk, IT Audit, Business Continuity/Disaster Recovery, Lawyers & Law Enforcement. The club provides an opportunity to network and have a few hours out to relax and socialise with peers.&
Attendance by RSVP only! Each RSVP is invited to bring a colleague or acquaintance for the purposes of introducing them to the club. Places are limited so please RSVP and ensure that you can attend. No-Shows who book a place may be removed from future STOTM event invitations.
How to join? search LinkedIN Groups for "STOTM - Second Thursday Of The Month club" and submit a request to join.Looking for more of the latest headlines on LinkedIn?当前位置:
诺华抗心衰药Entresto(TM)获欧盟正式批准
来源:中国药促会&&&
11月24日,欧洲委员会(EC)正式批准其抗心衰药Entresto(sacubitril/valsartan)用于治疗射血分数(HFrEF)降低的慢性心力衰竭成年患者,患者日均用药2次。Entresto具有独特的作用模式,能显著降低心脏张力,缓解心力衰竭。
该项批准是基于一项8442名患者参与的ARADIGM-HF临床研究,结果显示与ACE抑制剂enalapril相比,Entresto能显著降低心血管死亡的风险。治疗后期,使用Entresto的患者生存率更高,因心力衰竭而住院的几率较低。安全性数据显示Entresto与enalapril的耐受性相似。该项临床研究由于效果显著而提前终止。
“与其他慢性疾病相比,那些心力衰竭的患者面临更大的死亡风险,生活质量也更低。现在我们提供了一种全新的治疗选择,这将欧洲的射血分数(HFrEF)降低患者意义重大。”诺华制药的部门主管David Epstein说。
心力衰竭是一种危机生命的心脏疾病,患者心脏无法泵出足够的血液,因而面临着高风险死亡、反复住院治疗及其他症状(如呼吸困难,疲劳,体液潴留),该病会严重影响患者寿命及生活质量。
目前欧洲已有1500万名确诊患者,并且每年还新增10000名患者,其中大约一半以上的患者都存在射血分数减少的问题。尽管该病如此普遍,还是有很多患者未能确认该症状,被误诊或是误归为老年症状。
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2015年7月7日,美国食品与药物管理局(FDA)批准Entresto(LCZ696)用于心衰治疗;对于此项批准,人们在表示兴奋的同时,也表达了一些担忧。纳入超过8000例患者的PARADIGM-HF临床研究显示,与应用依那普利相比,应用Entresto可减少心血管死亡20%、因心衰住院21%、全因死亡16%,然而临床试验中并没有纳入很多存在合并疾病的患者。我们必须认识到,Entresto不是万能药,还未能完全治愈心衰,但其确实为治疗心衰提供了巨大的可能。关于Entresto的另一个问题是价格,Entresto的益处是否值得其不菲的价格?在美国,每粒Entresto的价格为6.25美元,即每天12.50美元,每人每年则高达4500美元。
2015年9月27日,欧洲药品管理局人用医药产品委员会(CHMP)推荐批准诺华的Entresto。 上传我的文档
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