双氯芬德巴金丙戊酸钠缓释片片是不是抗生药

来源：蜘蛛抓取(WebSpider) 时间：2015-02-23 03:29 标签： 路林双氯芬酸钠缓释片
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药学学报&2009,&44(7)&722-725&DOI:
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6&-纳曲醇单次和连续肌内注射给药在犬体内的药代动力学
颜玲娣1, 刘 军2, 董华进1, 崔孟珣1, 姚霞君1, 柳用绍1, 龚正华1, 宫泽辉1*
(1. 军事医学科学院毒物药物研究所, 北京 . 解放军第291医院药械科, 内蒙古 包头, 014040)
6&-Beagle (n = 4) 6&-& 0.2 mg&kg&1, 1, 7-6&-Beagle ()
(R2 & 0.999), t1/2& (0.26 & 0.23)
(0.19 & 0.18) h, t1/2& (4.77 & 1.65)
(5.79 & 1.50) h, Cmax (81.65 & 5.61)
(79.82 & 10.5) ng&mL&1, tpeak (0.27 & 0.07)
(0.18 & 0.08) h, CLs (1.20 & 0.06)
(1.12 & 0.07) L&kg&1&h&1, V/Fc (1.94 & 0.15)
(2.10 & 0.27) L&kg&1, AUC0&t (166.82 & 7.68)
(173.23 & 9.49) ng&h&mL&1 (P & 0.05),
&(79.03 & 10.3)
(1.50 & 0.93) ng&mL&1, 6&-, ;
6&-纳曲醇&&
Pharmacokinetics of 6&-naltrexol after single and multiple intramuscular injections in Beagle dogs
The pharmacokinetics of 6&-naltrexol (6&-NOL) following single intramuscular administration and multiple intramuscular injection once per day for seven days was studied in 4 Beagle dogs. &Plasma &&concentration of 6&-NOL in dogs was analyzed by a combination of high performance liquid chromatography (HPLC) and electrochemical detection with naloxone (NLX) as internal standard. &After single intramuscular injection of 0.2 mg&kg&1 6&-NOL, the plasma concentration-time curve of the drug was found to fit to a two &&compartment model with first-order absorption. &The main parameters of single dosing were as follows: t1/2& was (0.26 & 0.23) h, t1/2& was (4.77 & 1.65) h, Cmax was (81.65 & 5.61) ng&mL&1, tpeak was (0.27 & 0.07) h, CLs was (1.20 & 0.06) L&kg&1&h&1, V/Fc was (1.94 & 0.15) L&kg&1, and AUC0&t was (166.82 & 7.68) ng&h&mL&1, separately. &After multiple intramuscular injection of 0.2 mg&kg&1 6&-NOL once per day for seven days, the plasma &&&&&concentration-time curve of the drug fitted to a two compartment model with first-order absorption too. &The main parameters of the last dosing were as follows: t1/2& was (0.19 & 0.18) h, t1/2& was (5.79 & 1.50) h, Cmax was (79.82 & 10.5) ng&mL&1, tpeak was (0.18 & 0.08) h, CLs was (1.12 & 0.07) L&kg&1&h&1, V/Fc was (2.10 & 0.27) L&kg&1, and AUC0&t was (173.23 & 9.49) ng&h&mL&1, separately. &The difference of the parameters between the first and the last dosing was not significant, showing that the plasma kinetics of 6&-naltrexol was not changed after&&multiple administrations. &In the course of multiple administration, the peak and valley concentration of plasma 6&-naltrexol were (79.03 & 10.3) and (1.50 & 0.93) ng&mL&1, respectively. &No clear adverse events were noted during this study. &These results showed that plasma 6&-naltrexol fits to a two compartment model with first-order absorption in dog after intramuscular administration and their pharmacokinetic parameters were&&&reported. &There was no remarkable change on plasma pharmacokinetics of 6&-naltrexol after multiple&&&intramuscular administrations.
6&-naltrexol&&
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